Bioactive Small Molecules
AdipoGen Calcein-AM Solution (1 mg)
Chemical. CAS: 148504-34-1. Formula: C46H46N2O23. MW: 994.86. Calcein AM is a non-fluorescent cell permeable and hydrophobic probe that, upon entering live cells, is cleaved by intracellular esterases, releasing the membrane-impermeable, hydrophilic, and intensely bright green fluorescent calcein. Better retained by viable cells than fluorescein, carboxyfluorescein, or BCECF, due to its low cytotoxicity. It can be used as an indicator of cell viability (dead cells lack cytoplasmic esterases), cell-cell communication, cytotoxicity or changes in intracellular calcium, fluoride, iron or mercury. Calcein-AM is a neutral substrate for multidrug resistance-associated protein 1 (MRP1) and multidrug resistance protein 3 (MDR3, P-glycoprotein 3) and has been used in flow cytometry studies to analyze the function of P-gp and MRP. Used as a cytosolic fluorophore in mitochondrial permeability studies to image pore transition.
Medchemexpress LLC GNE-0946 | 1677667-24-1 | 98.1% | 10 MG
GNE-0946 is a potent, selective small-molecule agonist of the retinoic acid receptor-related orphan receptor γ (RORγ/RORc). It activates RORγ in HEK-293 cell-based assays with an EC50 of 4 nM. The compound is supplied as a research reagent for in vitro studies and is not intended for human or clinical use.
- Potent RORγ agonist (EC50 4 nM in HEK-293 cells).
- Selective activity suitable for ROR signaling studies.
- High purity (~98.1%) appropriate for biochemical assays.
- Chemical identity confirmed (CAS 1677667-24-1).
- Small-molecule format compatible with cell-based and biochemical experiments.
- Supplied as 10 mg for laboratory use.
Medchemexpress LLC Seralutinib | 1619931-27-9 | 99.94% | 469.53 | 100 MG
Seralutinib (GB002) is an inhaled PDGFRα and PDGFRβ inhibitor. It also targets CSF1R and c-KIT with IC50s of 8 nM and 14 nM, respectively. This product is used in the study for pulmonary arterial hypertension.
- Inhaled PDGFRα and PDGFRβ inhibitor
- Targets CSF1R and c-KIT
- Used in the study for pulmonary arterial hypertension
- Significantly reduces right ventricular systolic pressure and mean pulmonary artery pressure
- Reduces pulmonary arteriole muscularization
- Restores BMPR2 protein expression in the lung lobes
- Well tolerated
- Appearance: Solid, white to light yellow
Cayman Chemical ANTIBODY 852A 10mg
A TLR7 agonist; selectively induces NF-κB signaling in HEK293 cells expressing recombinant human TLR7 but not HEK293 cells expressing recombinant human TLR8 or TLR9 at 1 µM; induces IFN-α production in plasmacytoid dendritic cell-enriched isolated human PBMCs from 10-1,000 ng/ml; delays the onset of lung metastasis in a B16/F10 murine melanoma model at 150 mg/kg
Cayman Chemical C6 CeramIded18 16 0 Alkyn 5mg
A geranylgeranyl transferase I inhibitor (IC50 38 nM) 140-fold selective for GGTase I over farnesyltransferase (IC50 5400 nM) inhibits geranylgeranylation of RAP1A in vitro (IC50 10 UM) inhibits cell growth and decreases migration and invasion of OSSC cells to 75 45 and 27 of controls respectively prevents ovalbumin-induced eosinophil infiltration into airways in a mouse model of allergic bronchial asthma (5 mg/kg per day i.p.) decreases morphine withdrawal severity in rats (ED50 0.076 mg/kg)
Cayman Chemical ML-133hydrochlorIde 5mg
A Kir2 channel inhibitor (IC50s = 1.8, 2.8, 2,9, and 2.6 µM for Kir2.1, Kir2.2, Kir2.3, and Kir2.6, respectively); selective for Kir2 channels over Kir1.1 and Kir4.1 channels (IC50s = 33 and 76 µM, respectively); prevents the development of dynamic, but not punctate, mechanical allodynia in a mouse model of spared nerve injury at 10 and 30 nmol/animal
Medchemexpress LLC Azido-PEG1-C2-acid | 1393330-34-1 | 98.0% | 159.14 | 100 MG
Azido-PEG1-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Azide group. This allows it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing Alkyne groups. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups. PROTACs leverage the intracellular ubiquitin-proteasome system to facilitate the selective degradation of target proteins.
- PEG-based PROTAC linker
- Click chemistry reagent with azide group
- Participates in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc)
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
- Used in the synthesis of PROTACs
Cayman Chemical DabcylKSARSCoV2 ReplIcase 5mg
A fluorogenic substrate for SARS-CoV and SARS-CoV-2 Mpro; upon enzymatic cleavage by SARS-CoV or SARS-CoV-2 Mpro at the Gln-Ser site, EDANS is separated from the Dabcyl quencher and its fluorescence can be used to quantify SARS-CoV or SARS-CoV-2 Mpro activity
Cayman Chemical ANTIBODY TCN 201 1mg
A selective antagonist of NMDA receptors containing the NR2A subunit (pIC50s = 6.8 and <4.3 for human recombinant NR2A and NR2B, respectively); binds to a novel allosteric site located at the dimer interface between the GluN1 and GluN2 binding domains, thereby reducing glycine signal transduction and inhibiting NMDA receptor function
Cayman Chemical ANTIBODY ADH-1 5mg
A cyclic peptide antagonist of N-cadherin; inhibits neurite outgrowth in cerebellar neurons cultured on N-cadherin-expressing 3T3 cell monolayers (IC50 = 0.323 mM); inhibits cell scattering and motility induced by collagen I in Capan-1 cells and wild-type and N-cadherin-overexpressing BxPC-3 cells at 0.2 mg/ml; induces apoptosis in N-cadherin-overexpressing, but not knockdown, BxPC-3 at 1 mg/ml; reduces tumor growth in an N-cadherin-overexpressing BxPC-3 mouse xenograft model at 50 mg/kg
AdipoGen IHR-1 (1 mg)
Chemical. CAS: 548779-60-8. Formula: C20H12Cl4N2O2. MW: 454.1. Sonic hedgehog (Shh) signaling pathway inhibitor. Potential anticancer compound. Cell membrane impermeable Smoothened (Smo) antagonist. Acts on extracellularly exposed Smo only. Binds to the seven-transmembrane (7TM) pocket. Blocks hedgehog-induced movement of Smo into the primary cilium, disengages Smo-dependent abrogation of Gli2 and Gli3 proteolytic processing and inhibits Gli activity induced by loss of PTCH1.
Medchemexpress LLC HY-N0222 5mg Medchemexpress, Avicularin CAS:572-30-5 Purity:>98%
Medchemexpress, HY-N0222 5mg Avicularin CAS:572-30-5 Avicularin is a bio-active flavonoid from plants, anti-inflammatory, anti-allergic, anti-oxidant, hepatoprotective, and anti-tumor activities. Avicularin exhibits anti-inflammatory activity through the suppression of ERK signaling pathway in LPS-stimulated RAW 264.7 macrophage cells. Avicularin ameliorates human hepatocellular carcinoma via the regulation of NF κB (p65), COX 2 and PPAR γ activities[2]. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical ANTIBODY ML-18 5mg
A BB3 receptor antagonist; inhibits [125I]BA1 binding to NCI-H1299 lung cancer cells transfected with human BB3 receptors (IC50 = 4.8 μM); selective for BB3 over GRPR and NMBR (IC50s = 16 and >100 μM, respectively, in a radioligand binding assay); reversibly inhibits BA1-induced increases in cytosolic calcium in NCI-H1299 cells at 16 μM; inhibits BA1-induced phosphorylation of ERK and EGFR and reduces proliferation of NCI-H1299 cells