Bioactive Small Molecules
Cayman Chemical Pyrogallol, Purity: ≥98%, CAS: 87-66-1, 250 g
A natural oxidant that can generate O2- in alkaline solutions through autoxidation to a semiquinone radical, which in turn can react with O2- in an acidic environment to produce a quinone and H2O2; used in superoxide dismutase and antioxidant assays, as well as in biological systems
Medchemexpress LLC HY-13735A 100mg , Quinacrine (dihydrochloride) CAS:69-05-6 Purity:>98%
HY-13735A 100mg Quinacrine (dihydrochloride) CAS: 69-05-6 Quinacrine (Mepacrine) dihydrochloride is an orally bioavailable antimalarial agent, which possess anticancer effect both in vitro and vivo. Quinacrine dihydrochloride suppresses NF-κB and activate p53 signaling, which results in the induction of the apoptosis. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical PGS-IN-1, Purity: ≥95%, CAS: 102271-49-8, 25 mg
An NSAID and a dual inhibitor of COX and 5-LO (IC50s = 0.44 and 0.85 µM, respectively); selective for 5-LO over 12-LO (IC50 = >100 µM for 12-LO for the rabbit enzyme); inhibits paw swelling and bone damage in a rat model of M. butyricum-induced arthritis at 10 mg/kg per day, p.o.
![Medchemexpress LLC Pyridine, 5-cyclopropyl-2-[4-(2,6-difluorophenoxy)-5-methyl-3-(1-methylethoxy)-1H-pyrazol-1-yl] | 1800296-63-2 | 98.7% | C21H20F3N3O2 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000259344.png-250.jpg)
Medchemexpress LLC Pyridine, 5-cyclopropyl-2-[4-(2,6-difluorophenoxy)-5-methyl-3-(1-methylethoxy)-1H-pyrazol-1-yl] | 1800296-63-2 | 98.7% | C21H20F3N3O2 | 10MG
DHODH-IN-1 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor, reported as compound 18d, used in research on pyrimidine biosynthesis, antiviral activity, and cell proliferation. It shows strong DHODH inhibition (IC50 ≈ 25 nM) and is supplied as a high-purity research reagent with recommended dissolution in DMSO.
- Potent DHODH inhibitor with IC50 ≈ 25 nM.
- High purity (98.65%).
- Molecular formula C21H20F3N3O2; molecular weight 403.40.
- Available in small milligram pack sizes suitable for in vitro studies.
- Recommended solvent: DMSO; in vivo formulation protocol provided.
- Suitable for antiviral and cell-proliferation research.
- For research use only.
Enzo Life Sciences Rottlerin (10mg). CAS: 82-08-6
Mitochondrial uncoupler that depolarizes the mitochondrial membrane potential, reduces cellular ATP levels, activates 5‘-AMP-activated protein kinase (AMPK) and affects mitochondrial production of reactive oxygen species (ROS). Potent activator of multiple Ca2+-sensitive K+ channels. Blocks several kinases and non-kinase proteins in vitro. Has been widely-used as a selective inhibitor of protein kinase Cδ (PKCδ) (IC50=3-6µM). Although there is extensive published documentation to support the use of rottlerin as a selective PKCδ inhibitor, there has been some controversy in the literature over this claim. Some of this controversy may arise from the fact that rottlerin is a promiscuous inhibitor and therefore may not always display the same properties as would be expected from a classical 1:1 inhibitor. Alternative name: Mallotoxin. Purity: ≥98% (HPLC). Solubility: Soluble in DMSO (up to 50mg/ml). Long Term Storage: Ambient.
Cayman Chemical Arteannuin B, Purity: ≥98%, CAS: 50906-56-4, 5 mg
A precursor of artemisinin with diverse biological activities; active against a variety of bacteria and fungi in disk assays; reduces viral RNA levels in Vero E6 cells infected with SARS-CoV-2 (EC50 = 10.28 µM); cytotoxic to Ehrlich ascites tumor cells (IC50 = 47 µM)
Medchemexpress LLC 1-octanol-d17 | 153336-13-1 | MFCD00144995 | 99.1% | 147.33 | C8HD17O | 50 MG
1-Octanol-d17 is the deuterium-labeled analogue of 1-octanol supplied for research use. It provides deuterium labeling while retaining 1-octanol's chemical properties, enabling use as an isotopic tracer and analytical standard in mass spectrometry, mechanistic studies, and tracer experiments. Characterized by high isotopic and chemical purity, it is intended for laboratory research and analytical applications only.
- Deuterium-labeled form of 1-octanol for isotopic tracing.
- High isotopic and chemical purity suitable for mass spectrometry.
- Useful as an analytical standard and tracer in mechanistic studies.
- Reported to inhibit T-type calcium channels (native T-currents IC50 ~4 μM).
- Supplied in small pack sizes appropriate for analytical research.
Cayman Chemical BD 1047 (hydrobromide), Purity: ≥98%, CAS: 138356-21-5, 5 mg
A selective antagonist of σ1 receptors (Ki = 0.9 nM in a radioligand binding assay); selective for σ1 receptors with binding affinity values greater than 10,000 nM for human recombinant dopamine, opioid, PCP, and serotonin receptors in vitro; protects against convulsions and lethality induced by cocaine and reduces cocaine-induced locomotor activity; reduces haloperidol- and DTG-induced dystonias in vivo; attenuates mechanical allodynia and microglial activation in a rat model of bone cancer pain
Cayman Chemical Plerixafor, Purity: ≥95%, CAS: 110078-46-1, 1 g
An antagonist of CXCR4 (IC50s = 0.02-0.13 µg/ml); selective for CXCR4 over CXCR1-3 and CXCR5-9 (IC50s = >25 µg/ml); decreases infectious virus content in the supernatant of Jurkat cells chronically infected with HIV-1(IIIB) (EC50 = ~0.02 µg/ml); mobilizes murine and human hematopoietic stem and murine long-term repopulating cells for transplantation; increases T cell trafficking in mouse blood, spleen, and central nervous system; decreases the number of 4T1 murine mammary carcinoma cells in the lung in a mouse model of lung metastasis at 1.25 mg/kg twice per day
Cayman Chemical Chrysosplenetin, Purity: ≥98%, CAS: 603-56-5, 5 mg
A flavonoid with diverse biological activities; active against P. falciparum in vitro (IC50 = 23 µM); inhibits the cytopathic effect of EV71 in Vero cells (EC50 = 0.68 µM); increases survival in a neonatal mouse model of EV71 infection at 1 and 5 mg/kg; increases proliferation and osteogenic differentiation of isolated BMSCs; prevents estrogen deficiency-induced bone loss in ovariectomized mice
Cayman Chemical 3-hydroxy Desalkylgidazepam, Purity: ≥98%, CAS: 37891-18-2, 5 mg
An analytical reference standard categorized as a benzodiazepine; an active metabolite of gidazepam and desalkylgidazepam; has been used as a precursor in the synthesis of substituted benzodiazepinones; intended for research and forensic applications
Medchemexpress LLC CDK2 degrader 5 | 2923574-11-0 | 99.2% | 497.54 | 25 MG
CDK2 degrader 5 (compound 12) is a degrader for CDK2, with a Dmax of >50% and ≤80% in HiBiT Assay. It plays an important role in cancer research.
- Degrader for CDK2.
- Dmax of >50% and ≤80% in HiBiT Assay.
- Used for research purposes only.
- Solid, white to off-white appearance.
- Plays an important role in cancer research.
Medchemexpress LLC Dioxopromethazine hydrochloride | 15374-15-9 | MFCD01706903 | 100.0% | 352.88 g·mol⁻¹ | C17H21ClN2O2S | 50 MG
Dioxopromethazine hydrochloride is a phenothiazine-derived, orally active antihistamine used in preclinical research to study histamine-mediated responses and to investigate inhibition of asthmatic symptoms. Supplied as a hydrochloride salt with high reported purity, it is intended for laboratory research use only.
- Orally active compound suitable for in vivo and in vitro research.
- Modulates histamine-related pathways and may inhibit asthmatic symptoms.
- Provided as a hydrochloride salt to aid solubility in polar solvents.
- High reported purity appropriate for research applications.
- Available with safety data sheet and technical documentation for laboratory handling.
Medchemexpress LLC N-hydroxymethyl succinimide | 5146-68-9 | MFCD01328751 | 95.0% | 129.11 g/mol | C5H7NO3 | 5 G
N-hydroxymethyl succinimide is a promoiety used as a prodrug carrier for non-steroidal anti-inflammatory drugs (NSAIDs). It enhances the lipophilicity of parent compounds and can reduce gastrointestinal toxicity, making it suitable for research into anti-inflammatory drug delivery systems.
- Used as a prodrug promoiety for NSAIDs
- Enhances lipophilicity of parent drugs
- May reduce gastrointestinal toxicity in formulations
- Chemical formula C5H7NO3; molecular weight 129.11 g/mol
- CAS number 5146-68-9
- Powder storage: -20°C (3 years), 4°C (2 years)
Medchemexpress LLC TH1834 dihydrochloride | 2108830-09-5 | ≥99.0% | 641.63 | C33H42Cl2N6O3 | 5MG
TH1834 dihydrochloride is the dihydrochloride salt of TH1834, a small-molecule inhibitor of the Tip60 (KAT5) histone acetyltransferase used in cellular and biochemical research to probe histone acetylation, apoptosis, and DNA damage responses. The compound has chemical formula C33H42Cl2N6O3, molecular weight 641.63, and CAS 2108830-09-5; it is supplied as a high-purity research reagent.
- Specific Tip60 (KAT5) histone acetyltransferase inhibitor.
- Dihydrochloride salt form for improved solubility.
- High purity suitable for research (≥99.0%).
- Supplied as a small research sample (5 mg).
- Used in studies of apoptosis and DNA damage responses.
- For research use only; not for clinical or diagnostic applications.